Search Wars Episode II. Yebol a new search!

One of my recent post discussed the dawn of the new era and new breed of search engines Search Wars.

YEBOL a youngling from the the Stanford stable, a new search in the block. Yebol's mission is to build human-like world's knowledge base and provide knowledge based search (semantics) and services.

Yebol utilizes a combination of patented algorithms paired with human knowledge to build a Web directory for each query and each user. Instead of the common “listing” of Web search queries, Yebol automatically clusters and categorizes search terms, Web sites, pages and contents.

Yebol allows for a multi-dimensional search result instead of the normal one-dimensional search seen by most web search engines today. This provides a more accurate summary of top sites and categories; a wider array of related search terms; a longer and richer expansion for query results; and a deeper base of links and keywords in search result pages.

Unlike current search platforms, Yebol provides hundreds of easily identified and accessibly categorized results in one easily navigable page. The results not only provide users with a rich search experience, but also help them quickly scan the results to find targeted information. In essence, generate a unique “homepage look” for each search query.

Yebol provides a productive experience for both main types of search – general investigation of a topic and specific target search. For users who want to research and explore a topic, Yebol provides rich information from several dimensions. For users who want a specific type of targeted results, they can quickly focus on their category and navigate to the target.

A search for APOE, top most hit (first) gave a expanded definition Apolipoprotein E - on Wikipedia. Followed by link to GHR, wikigenes, gene cards, AD genetics fact sheet form NIA.

It also gives live context sensitive Twitter streaming too.

XTractor Premium - A Platform for discovery, knowledge sharing, analysis and modelling of published biomedical facts.

• The only Knowledgebase which provides "manually" annotated facts from PubMed on a weekly basis
  
• Innovative Features like Semantic Search, Concept Linking, Bibliographic search, Save, Export and Visualize
  
• Only Knowledgebase with daily updations from PubMed
  
• XTractor Premium now at an Special Introductory Offer. Subscribe now and save!
  
• Request for a Trial
  

Search Wars

A not very long time ago, in a galaxy near,
very near by....

SEARCH
WARS

Search, Search engines, While the Search engine big wigs fight for a niche in the search engines landscape .... The Google, Yahoo & now Micorsoft too (with their Bing)

There are the Wolfram|Alpha likes that are forming a separatist and slowly gaining power over the Google order. In fact google has managed to bring balance to both with its Google Squared.

While platforms like XTractor, NextBio, Novoseek, GoPubMed, BioMedSearch have specialized in searching biomedical and biological knowledge are even more strengthening the separatists.

Now to see and know who is more powerful, the galactic empire or the separatist? I leave it to the 'Republic' i.e. You users! to judge, in the form of your comments and experiences with such tools and searches! you could even voice your opinions here

Indian researchers find the pathway to cancer

BANGALORE, Indian Researchers have achieved a breakthrough, identifying a protein pathway that triggers cancer in the human body owing to its erratic behaviour.

Researchers at Bangalore’s National Centre for Biological Sciences (NCBS) led by Satyajit Mayor and Neha Vyas have identified what is known as the Hedgehog pathway and the ways in which it forms and leads to cancer. The researchers, who have published their work in the journal, Cell, say this pathway is formed when the proteins (called hedgehog), which are separate, get drawn to each other by electrostatic interactions between amino acids present around the proteins.

A small cluster of proteins then gets formed and goes on to form a mega-cluster. This travels to other cells and creates effects that are good or bad — the cluster could be normal and help organ regeneration or tissue repair, or the cluster could get hyperactive and affect other cells, which is the sign that cancer is coming.

Simply put, the NCBS research indicates that hyperactivity of the hedgehog proteins within the human body can cause cancer and that its cluster formation has to be prevented to eliminate the possibility of hyperactivity entirely.

“Identifying the initial step that initiates the electrostatic attraction between amino acids that bring together hedgehog proteins in a cluster might help other scientists to design an anti-cancer drug that could stall a mutant hedgehog pathway in effective ways,” Said Neha. Such a drug could target the very source of these attractions — the amino acids that cause them — which are the first cause of cancer.

XTractor Premium - A Platform for discovery, analysis and modelling of published biomedical facts.

• The only Knowledgebase which provides "manually" annotated facts from PubMed on a weekly basis
  
• Innovative Features like Semantic Search, Concept Linking, Bibliographic search, Save, Export and Visualize
  
• Only Knowledgebase with daily updations from PubMed
  
• XTractor Premium now at Introductory Offer of $450 for Academic Researchers. Subscribe now and save $300!
  
• Register for WebEx
  
• Request for a Trial
  
  

Freely mining PUBMED for your drug discovery needs everyday

Biomedical Data mining happens to be a long-standing problem in scientific research. Scientists are constantly in search of newer and innovative means to mine biomedical data.

Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service, that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are categorized into biological significant relationships and it also provides the user with the ability to create his own database for a set of Key terms. Also the user could change the Keywords of preference from time to time, with changing research needs. The categorized sentences could then be tagged and shared across multiple users. Thus XTractor proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate.

Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.

XTractor crosses 150 user registration in 3 weeks!!!!

• XTractor now has over Over 150 registered users from FDA, NIH, NCI, Astra Zeneca, Wyeth,MD Anderson Cancer Institute, Washington university, Scripps institute, Max Planck, Harvard Medical schooland many more in less than 3 weeks !!!
• More than 600 annotated facts added everyday.
• A total of 25,000 facts added till date!!!

Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service, that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are categorized into biological significant relationships and it also provides the user with the ability to create his own database for a set of Key terms. Also the user could change the Keywords of preference from time to time, with changing research needs. The categorized sentences could then be tagged and shared across multiple users. Thus XTractor proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate.

Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.

Research Exposes New Target For Malaria Drugs

The malaria parasite has waged a successful guerrilla war against the human immune system for eons, but a study in this week's Journal of Biological Chemistry has exposed one of the tricks malaria uses to hide from the immune proteins, which may aid in future drug development. Malaria parasites (plasmodia) are transmitted to people via infected mosquitoes. Once inside their human hosts the parasites first set up shop in liver cells, then move into red blood cells (RBCs) to replicate and wait for the next mosquito to help continue the cycle. After plasmodia infect a blood cell, they send out clusters of sticky proteins to the cell surface, enabling them to attach to blood vessels and escape destruction by the host's spleen while they replicate. This tactic can be especially problematic during pregnancy as malaria-infected RBCs congregate in the vessel-rich placenta (the source of food and oxygen for the growing fetus), creating health problems such as anemia, low birth-weight, fever and more.

Targeting these sticky proteins with drugs is difficult, however, as plasmodia contain many different varieties, which they use to evade the human immune system. However, certain parts of the protein have to remain constant for proper function, and in this study, Matthew Higgins generated high-resolution 3-D structures of a malarial sticky protein that binds to placenta, PfEMP1, to detail how plasmodia protect these conserved areas. Higgins found that a variable region of PfEMP1 covers a section that is important for docking up with the placental wall. When the infected RBC gets close to chondroitin sulphate, a structural molecule on blood vessels, the variable region moves aside and ever so briefly exposes the binding region, just enough to allow anchoring to take place. Higgins notes that women in regions where malaria is endemic do gain some immunity to the build-up of RBCs at the placenta after multiple pregnancies by developing an immune response for PfEMP1. Targeting this conserved binding domain of the protein with pharmaceuticals that mimic chondroitin sulphate and expose this region might be an approach to hasten this immunity.

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria.

Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service, that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are categorized into biological significant relationships and it also provides the user with the ability to create his own database for a set of Key terms. Also the user could change the Keywords of preference from time to time, with changing research needs. The categorized sentences could then be tagged and shared across multiple users. Thus XTractor proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate.

Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.

Launch of XTractor™ -a powerful scientific literature alert & abstraction system, now with unlimited free access.

Bangalore, India — Indian Life Sciences Informatics Company, Molecular Connections announced today, the release of XTractor™, a first of its kind manually curated literature alert service. XTractor™ can be accessed free of charge by the scientific community world wide.

XTractor™ acts as a literature alert service, which provides scientists with manually annotated scientific facts from literature. It enables researchers to be up-to-date with the latest scientific publications in the STM arena, as and when they are published. Once registered the scientists have the freedom to choose their keywords of choice and also set the frequency at which they wish to receive these alerts.

Mining scientific literature to retrieve accurate hits or extract entity relationship has always been a long-standing problem in research. It is a daunting task to identify the right gene name or the right drug name and extract relations/association with diseases, processes; pathways etc accurately form unstructured text. Text mining engines are fast enough but not accurate. XTractor™ with its efficient workflows combines the speed of a text-mining engine, with the accuracy of manual, expert curation.

XTractor™ is highly accurate and more efficient than many of NLP engines, since it is a hybrid model using technology and manual validation. Since the annotation is highly accurate researchers would also be able to perform complex queries and retrieve the most complex relations available in literature, which is currently not possible with the conventional NLP systems. Other than this XTractor™ acts as a platform for data sharing and categorization. Scientists can share their data with others and even tag data into customized datasets. Above all the data stored in one’s profile is accessible anytime, anywhere.

J Kamesh, Business Development Manager at Molecular Connections mentioned, “XTractor™ is a technology, which can and should be used by all life science researchers who want to stay current and updated in their field of interest. XTractor™ provides scientists with the ability to customize his own data needs. The researchers have the flexibility to change their keywords in tune with their changing research needs. The alerts get updated automatically for the new set of Keywords.”

To know more about the advantages of the XTractor™ and to register for a free trial account please logon to the Molecular Connections’ XTractor portal www.XTractor.in.

About Molecular Connections

Molecular Connections is a pioneering In silico discovery services company. It provides high quality, cost effective curation, literature informatics solutions and annotation services as well as products. Dr.Limsoon Wong is the Chairman of Molecular Connections. Customers of Molecular Connections include leading pharmaceutical and biotechnology, drug discovery, genomics, proteomics, medical technology, equipment companies and academic institutions spanning across the globe.

Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service, that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are categorized into biological significant relationships and it also provides the user with the ability to create his own database for a set of Key terms. Also the user could change the Keywords of preference from time to time, with changing research needs. The categorized sentences could then be tagged and shared across multiple users. Thus XTractor proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate.

Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.

Genes for schizophrenia uncovered

Three separate research projects have pinpointed genetic flaws linked to schizophrenia.

One of these, reported in the journal Nature, could mean a fifteen-fold increase in risk.However, one of the researchers warned that schizophrenia is so complex genes alone will only ever partially explain the illness at best. Scientists have suggested that an individual's risk of schizophrenia is roughly half dictated by their genetic make-up, and half by other factors during their lives. However, on both sides of this equation, much has still to be revealed about the precise causes. The three large-scale projects have taken a step towards unravelling the genetic picture of schizophrenia.

Do you want to know more?

Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service, that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are categorized into biological significant relationships and it also provides the user with the ability to create his own database for a set of Key terms. Also the user could change the Keywords of preference from time to time, with changing research needs. The categorized sentences could then be tagged and shared across multiple users. Thus XTractor proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate.

Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.

Launch of XTractor™ -a powerful scientific literature alert & abstraction system, now with unlimited free access.

Bangalore, India — Indian Life Sciences Informatics Company, Molecular Connections announced today, the release of XTractor™, a first of its kind manually curated literature alert service. XTractor™ can be accessed free of charge by the scientific community world wide.

XTractor™ acts as a literature alert service, which provides scientists with manually annotated scientific facts from literature. It enables researchers to be up-to-date with the latest scientific publications in the STM arena, as and when they are published. Once registered the scientists have the freedom to choose their keywords of choice and also set the frequency at which they wish to receive these alerts.

Mining scientific literature to retrieve accurate hits or extract entity relationship has always been a long-standing problem in research. It is a daunting task to identify the right gene name or the right drug name and extract relations/association with diseases, processes; pathways etc accurately form unstructured text. Text mining engines are fast enough but not accurate. XTractor™ with its efficient workflows combines the speed of a text-mining engine, with the accuracy of manual, expert curation.

XTractor™ is highly accurate and more efficient than many of NLP engines, since it is a hybrid model using technology and manual validation. Since the annotation is highly accurate researchers would also be able to perform complex queries and retrieve the most complex relations available in literature, which is currently not possible with the conventional NLP systems. Other than this XTractor™ acts as a platform for data sharing and categorization. Scientists can share their data with others and even tag data into customized datasets. Above all the data stored in one’s profile is accessible anytime, anywhere.

J Kamesh, Business Development Manager at Molecular Connections mentioned, “XTractor™ is a technology, which can and should be used by all life science researchers who want to stay current and updated in their field of interest. XTractor™ provides scientists with the ability to customize his own data needs. The researchers have the flexibility to change their keywords in tune with their changing research needs. The alerts get updated automatically for the new set of Keywords.”

To know more about the advantages of the XTractor™ and to register for a free trial account please logon to the Molecular Connections’ XTractor portal www.XTractor.in.

About Molecular Connections

Molecular Connections is a pioneering In silico discovery services company. It provides high quality, cost effective curation, literature informatics solutions and annotation services as well as products. Dr.Limsoon Wong is the Chairman of Molecular Connections. Customers of Molecular Connections include leading pharmaceutical and biotechnology, drug discovery, genomics, proteomics, medical technology, equipment companies and academic institutions spanning across the globe.

In addition, Molecular Connections has powerful tool development, database integration and effective data visualization capabilities. Molecular Connections has specific expertise in building knowledge bases for rapidly growing needs in genomics, proteomics, ADME Tox, clinical, drugs, chemistry and patent industries.

New Drug Reverses Alzheimer's Disease Within Days In Mouse Models

Scientists report a remarkable improvement in Alzheimer's transgenic mice following treatment with a new drug. The study provides the first demonstration that an ionophore, a compound that transports metal ions across cell membranes, can elicit rapid and pronounced improvement in neuropathology and cognitive function in mouse models of Alzheimer's Disease (AD).

Recent research has implicated dysregulation of metal ions in the brain, particularly copper and zinc, in the pathogenesis of AD and the damaging accumulation of amyloid beta (Aβ) protein that is characteristic of this devastating disease. The ionophore clioquinol (CQ), an 8-hydroxyquinoline, has been shown to increase intracellular copper and zinc levels and decrease Aβ levels in cultured cells and in the brains of transgenic (Tg) AD mice. However, further studies in mice and humans demonstrated that brain entry of CQ was quite limited.

This research is published by Cell Press in the July 10th issue of the journal Neuron.