Research Associate and Senior Research fellow @ IARI

Courtesy
 Bioclues

Applications are invited in prescribed pro forma for the following posts under the projects mentioned along with the post, detailed qualification and pay etc. of the posts are given below:

Post 1 : Research AssociateProject : “Functional significance of Potyviral Hc-Pro interaction with host and vector factors” DST funded Indo-Spanish bilateral programme (PI- Dr. Shelly Praveen)
No of post : One
Essential Qualification : Ph.D. degree or M.Sc. with three years research experience in Biochemistry/Plant Pathology / Biotechnology or a related field.
Job requirement : Job requirement include study of the interaction of viral RNAi suppressor protein Hc-Pro and proteins involved in plants’ RNAi machinery with the overall goal to establish the host – viral interaction. Research will include Cloning, mutation work, protein and gene expression and bioinformatics analysis. Host-viral interaction studies include yeast two hybrid system, YFP and GFP vector based techniques.
Desirable :i) Publications in the desired field of research
ii) Experience in handling softwares involved in Life Sciences research.
Pay : Rs 22,000/-P.M. (Consolidated) + HRA as admissible

Post 2 : SRFProject : “RNAi and other cutting edghe technological intervention to develop insect pests, diseases and virus tolerant tomato hybrids for Indian and International market.” BIPP, DBT (PI- Dr. Shelly Praveen) 
No of post : One
Essential Qualification : M.Sc. in Plant Pathology.
Job requirement : Job requirement include standardization of protocol for transmission of Tospo & Gemini viruses and screening of transgenic tomato lines for resistance
Desirable : i) Two to three years experience in the relevant field with proven published record.
ii) Experience in handling softwares involved in Life Sciences research
Pay : Rs 14,000/-P.M. (Consolidated) + HRA as admissible

The eligible candidates may apply on prescribed pro forma only through ordinary post. No other documents like attested copies of testimonials or research papers should be attached. Candidates are advised to write the name of the post applied for and project on top left of envelop. Applications must reach the Principal Investigator, Division of Plant Pathology, IARI, New Delhi-110012 within 15 days from the date of appearance of advertisement in News paper/ IARI website. Call letter will be issued for interview to the selected candidates after screening.

Deadline : 08.03.12

http://www.iari.res.in/files/patho-ra-srf--20120222-165134.pdf

Workshop - "In-silico Drug Discovery Based on the Integration of Bioinformatics and Chemoinformatics"

The Workshop

Drug discovery is an expensive and time taking process and therefore new approaches based on chemoinformatics and bioinformatics are being adopted.The knowledge of the 3D structures of protein targets is now playing a major role at all stages of drug discovery. The distinct nature of biological and chemical information requires the integrated capabilities of both bioinformatics and chemo-informatics to decipher existing and hidden relationships. Bioinformatics and chemo-informatics have largely evolved independently from biology and chemistry. Cheminformatics is an inter-disciplinary subject of storage, processing and retrieval of chemical information. Bioinformatics and chemoinformatics have significantly assisted in lead optimization, fingerprinting, pharmacophore designing, target identification, QSAR and their application can lead to discovery of new molecules. Molecular modeling using 3D graphics and optimization techniques helps the scientists to understand how drugs bind to proteins in the body. Classically, protein structure has been exploited in lead optimization, a process that uses structure to guide the chemical modification of a lead molecule to give an optimized fit in terms of shape, hydrogen bonds and other non-covalent interactions with the target. Protein structure can also be used in target identification and selection.

Any homologue of identified known structure can be modeled using a variety of comparative modeling procedures. Lead modification is used for modification in order to improve desired pharmacological properties. A small part of a lead compound may be involved in the appropriate interaction. The relevant groups on a molecule that interact with receptor and are responsible for activity are collectively known as pharmacophore.

The workshop aims:

1. To familiarize the researchers and students with applications of bioinformatics and chemoinformatics in drug discovery.
2. To familiarize participants with current advances in the macromolecule structure prediction, including protein structure, protein folding, molecular dynamics and simulation.
3. To acquaint participants with in- silico chemical and structural fingerprinting, designing and preparation of lead molecules for drug designing and various tools and techniques to bioinformatics and chemoinformatics.

Objectives

The participants of the workshop will be accessing online resources of macromolecule libraries, sketching chemical compounds and building 3-D molecules, drug designing. They would also learn about prediction and analysis of various properties of compounds, bimolecular and structure prediction and visualization and analysis. The practical knowledge gained through this workshop will help them in enhancing their skills in utilizing tools for their application in basic and industrial research and employment potential.

Workshop Contents

The workshop will consist of lectures, group discussions, case studies, exchange & sharing of experience on :

• Bioinformatics and its application
• Biological Databases
• Functional Genomics and Proteomics
• Structural Bioinformatics
• Proteins 3-D Structure Prediction
• Drug Designing & Case study
• Science involved in disease target identification
• Pocket/ Active site identification
• Lead identification and optimization
• In-silico generation of novel ligand molecules
• Target ligand docking
• 3-D Quantitative Structure Activity Relationships
• Rational drug discovery
• RNA Interference

Who should attend?

Scientists / Research fellows (National Laboratories & Universities) and Graduate / Post graduate students in Engineering / Biological / Chemical sciences/ Medical discipline.

Duration

February 23 – 25, 2011

Venue

Biotech Park,

Sector-G, Jankipuram,

Near Biotech Square, Kursi Road,

Lucknow-226021, (U.P.), India.

E-mail : info@biotechpark.org.in, sna.biotechpark@gmail.com

www.biotechpark.org.in

Number of Participants

SEATS ARE AVALABLE.

Registration Fee

Rs 2,000/- per participant. The registration fee includes lectures/presentation handouts, stationary, local transportation, lunch and tea. Fee is to be paid through bank draft drawn in favour of “CEO, Biotech Park, Lucknow”, Completed registration form along with the fee should reach, CEO, Biotech Park on or before February 21, 2011.

Do you wish to know more?