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Algorithm tailored for short-read data from single cells that improves assembly

Abstract

Whole genome amplification by the multiple displacement amplification (MDA) method allows sequencing of DNA from single cells of bacteria that cannot be cultured. Assembling a genome is challenging, however, because MDA generates highly nonuniform coverage of the genome. Here we describe an algorithm tailored for short-read data from single cells that improves assembly through the use of a progressively increasing coverage cutoff. Assembly of reads from single Escherichia coli and Staphylococcus aureus cells captures >91% of genes within contigs, approaching the 95% captured from an assembly based on many E. coli cells. We apply this method to assemble a genome from a single cell of an uncultivated SAR324 clade of Deltaproteobacteria, a cosmopolitan bacterial lineage in the global ocean. Metabolic reconstruction suggests that SAR324 is aerobic, motile and chemotaxic. Our approach enables acquisition of genome assemblies for individual uncultivated bacteria using only short reads, providing cell-specific genetic information absent from metagenomic studies.

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PerkinElmer to Acquire Caliper Life Sciences for Approximately $600 Million

PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, today announced that it has signed a definitive agreement to acquire Caliper Life Sciences, Inc., a Hopkinton, Massachusetts-based leader in imaging and detection solutions for life sciences research, diagnostics and environmental markets, for $10.50 per share, for a total net purchase price of approximately $600 million in cash.

Robert F. Friel, chairman and chief executive officer, PerkinElmer, said, "The acquisition of Caliper Life Sciences brings innovative molecular imaging and detection technologies to our portfolio, complementing our world-leading offerings in life science, diagnostics, environmental and food markets."

Friel added, "The R&D, application expertise, and intellectual property of the combined organization will provide our customers with enhanced knowledge and services and a strong pipeline of innovation. Additionally, the proven leadership and talent of the Caliper team will be a strong addition to our organization."

The combined technology platforms will expand PerkinElmer's deep portfolio of solutions and services for global customers.

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International Conference on Perspective of Cell Signaling and Molecular Medicine

2nd International Conference on Perspective of Cell Signaling and Molecular Medicine  8 to 11 January, 2012 Organised by Bose Institute, Kolkata

Instructions for Submission of Abstract :

1. Only abstracts containing new results will be accepted. Abstracts should clearly and adequately describe the objectives and results of the research. All abstracts must be submitted in English. All abstracts must be accompanied by a completed Conference Registration Form made out in the name of one of the Authors.
a. Each abstract should include a title (in capital letters), name(s) of all authors (underline the presenting author), affiliation and email address.
b. Type entire abstract single-spaced; typing area: width 12.0 cm (4.7 inches), height 24 cm (9.4 inches).
c. Careful typing and proof-reading are essential.

Registration :

• Registration fees : Rs. 4,000/ (Scientist); Rs. 2,500/ (Students including post-docs)


• Late Registration fees : Rs. 5,000/ and Rs. 3,500/ respectively


• Accompanying persons : Rs. 3,000/ and Rs. 2,000/ respectively


• $300  (Foreign participants); $200 (Foreign students)

Contact :Prof. Parimal C. Sen
Secretary,
International Conference on Perspective of Cell Signaling and Molecular Medicine
Bose Institute,
P-1/12 CIT Scheme VII M,
Kolkata-700 054, India.
Tel: +91-33-2569-3222; +91 9433012797 (Cellular)
Fax:  +91-33-2355-3886
E-mail: parimal@bosemain.boseinst.ac.in | parimalsen.boseinst@gmail.com

Dead-line for Registration : November 15, 2011